1 “ Distinguishing direct versus indirect transcription factor - DNA interactions ”
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P<P Published online August 3, 2009 in advance of the print journal. Open Access This manuscript is Open Access. Preprint Accepted likely to differ from the final, published version. Peer-reviewed and accepted for publication but not copyedited or typeset; preprint is service Email alerting click here top right corner of the article or Receive free email alerts when new articles cite this article sign up in the box at the
منابع مشابه
Distinguishing Direct versus Indirect Transcription Factor-DNA Interactions
Transcriptional regulation is largely enacted by transcription factors (TFs) binding DNA. Large numbers of TF binding motifs have been revealed by ChIP-chip experiments followed by computational DNA motif discovery. However, the success of motif discovery algorithms has been limited when applied to sequences bound in vivo (such as those identified by ChIP-chip) because the observed TF-DNA inter...
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Distinct automatic and controlled processes are presumed to influence social evaluation. Most empirical approaches examine automatic processes using indirect methods, and controlled processes using direct methods. We distinguished processes from measurement methods to test whether a process distinction is more useful than a measurement distinction for taxonomies of attitudes. Results from two s...
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Computer Science) Protein-DNA Binding: Discovering Motifs and Distinguishing Direct From Indirect Interactions by Raluca M. Gordân Department of Computer Science Duke University Date: Approved: Alexander J. Hartemink, Advisor Uwe Ohler Bruce R. Donald David M. MacAlpine An abstract of a dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in t...
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BACKGROUND The elucidation of mammalian transcriptional regulatory networks holds great promise for both basic and translational research and remains one the greatest challenges to systems biology. Recent reverse engineering methods deduce regulatory interactions from large-scale mRNA expression profiles and cross-species conserved regulatory regions in DNA. Technical challenges faced by these ...
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تاریخ انتشار 2009